| 16 July | vs Wigan Athletic (Friendly) | 13:30 uk | DW Stadium, Wigan |
| 22 July | vs Borussia Dortmund (Friendly) | 13:00 uk | Shanghai, China |
| 25 July | vs Manchester City (Friendly) | 12:30 uk | Beijing, China |
| 30 July | vs Galatasaray (Friendly) | 18:30 uk | Sweden |
| 07 August | vs Leicester City (Community Sheild) | 17:30 uk time | Wembley, London |
| 13 August | AFC Bournemouth | 12:45 uk | Dean Court |
| 19 August | Southampton | 19:45 | Old Trafford |
| 27 August | Hull City | 17:30 | KCOM Stadium |
| 10 September | Manchester City | 12:30 | Old Trafford |
| 15 September | Europa League starts | 20:00 | Old Trafford |
| 18 September | Watford | 12:00 | Vicarage Road |
| 24 September | Leicester City | 12:30 | Old Trafford |
| 01 October | Stoke City | TBC | Old Trafford |
| 15 October | Liverpool | TBC | Anfield |
| 22 October | Chelsea | TBC | Stamford Bridge |
| 29 October | Burnley FC | TBC | Old Trafford |
| 05 November | Swansea City | TBC | Liberty Stadium |
| 19 November | Arsenal | TBC | Old Trafford |
| 27 November | West Ham | TBC | Old Trafford |
| 03 December | Everton | TBC | Goddison Park |
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